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SVC syndrome gone awry

Posted By Wesley A. Gabbard, Sunday, January 1, 2017

I have been meaning to present this case for a while. This case taught me many different lessons. Firstly, never trust what anyone says (even yourself) about what can and cannot be done. Secondly, always have a plan B, and, hopefully, a plan C.

 

This was a patient that I had known for years. At the time he was 49 years old. He had had multiple attempts at a permanent dialysis access with each failing early after creation or within a few months to years. This was in spite of mapping and aggressive maturation procedures as well as active surveillance/monitoring. Part of the issue was non-compliance on his part, but, also, he seemed to stenose quickly and easily despite even stenting. He had accrued multiple medical conditions in his young life, including: coronary artery disease and peripheral vascular disease in addition to diabetes, obesity, and hypertension. He was poor surgical candidate for anything extremely invasive.

 

Interestingly, he had also developed SVC syndrome that was symptomatic (he had a swollen head). At the University, a CT of the chest showed the SVC occlusion. The local expert in central vein stenoses said "there was nothing to do".

 

I had seen him multiple times for access issues, but, for some reason, after his last graft had failed, he went to the local hospital where a surgeon placed the tesio catheters. Yes, there is a RIJ vein tesio with a cephalad venotomy site and a left SCV tesio. He was sent to me due to poor function of the tesios.

 

I was able to cut down to the RIJ vein tesio after an angiogram showed no blood flow to the right atrium. Using a 180-cm stiff straight Glidewire and guiding Berenstein catheter, I was able to pass the guidewire through the occlusion (after removing the internal portion of the tesio and cleaning the guidewire). Amazingly, the guidewire passed through the right heart and into the IVC. I, then, dilated the SVC with a 12mm Conquest catheter with 80-90% residual due to elasticity. So, I decided to stent the SVC. I deployed a 14mm by 4cm Luminexx stent, that although I allowed time for it to expand and with the occlusion in the middle of the stent, the stent traveled forward and dropped into the right atrium. Thankfully, the stent was still on the guidewire. Now, I was in a dilemma. I was in an outpatient center with a patient who would likely not survive open heart surgery. If the stent embolized, he would likely die as well. I could not grab the stent with anything. A 14mm by 4cm Atlas catheter passed right through the stent. Additionally, the IVC appeared to come off the right atrium somewhat anteriorly which kept the stent from passing out of the heart. The one image shows the stent in the right atrium, but it is somewhat faint. Finally (after trying multiple ideas), I was able to grab the stent with an 18mm by 4cm Atlas catheter and pass it through the right atrium and park it in the IVC. I performed an angiogram that showed successful placement in the IVC.

 

Now, I still had the occluded SVC. The blood flow was through the azygous system. Therefore, I deployed a second 14mm by 4cm Luminexx stent in basically the same fashion as the first one (but, making certain that it did not travel even the slightest). It was placed across the occlusion and seated with the 14mm by 4cm Atlas catheter. There was about 20% residual stenosis, but blood flowed into the right atrium.

 

To make matters worse, the surgeon had placed the RIJ vein tesio with a cephalad venotomy site as the RIJ vein was occluded at the clavicle. Therefore, I cannulated an 8mm by 4cm Vaccess catheter at the clavicle that been used to dilate the RIJ vein and right innominate veins using the 180-cm stiff straight Glidewire that was already in place. I used this new venotomy site to place a RIJ vein tunneled dialysis catheter. I collapsed the balloon around the micro-wire after inserting it into the balloon using the 21 gauge needle. I had cannulated the balloon with this needle using ultrasound guidance just cephalad to the clavicle. Remember, this patient was obese and had a short neck which made this cannulation difficult. The micro-wire and balloon were passed centrally giving me a venotomy site just cephalad to the clavicle to keep the catheter from kinking. With a nicely functioning RIJ vein tunneled dialysis catheter, I also removed the left SCV tesio.

 

Therefore, like I said. Never trust anyone, even yourself. Sometimes, we just need to try a case and find out if there is nothing left to do. And, always have a Plan B and a Plan C (if you can).

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Tags:  Central Stents  central vein stenosis  tunneled dialysis catheter 

Permalink | Comments (19)
 

Comments on this post...

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Marc Webb says...
Posted Sunday, January 1, 2017
Lucky the wire traversed the heart into the IVC.
Stents being deployed can move either way depending on asymmetric resistance but more often shoulder forward than be pushed back. For this reason I will frequently ask for the stent to be placed retrograde from the femoral approach, anchoring the expanding edge of the stent cephalad before deploying it completely.
Great case, but it's a little like describing how you scared off a grizzly bear with a loud transistor radio playing Taylor Swift - you live through the event, but then resolve to quit camping.
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Wesley A. Gabbard says...
Posted Sunday, January 1, 2017
Dr, Webb.
That is a great point, but not always easy to do in an outpatient access center. Changing to a femoral approach during a case can be time consuming (although I am not trying to defend anything that I did). When patients are lined up for procedures throughout the day, even when they wait 45 minutes, they complain. I agree that the patient comes first. Still, this patient was quite obese, and I really did not know what I would find when I got into the case. I did not realize the tesios were not placed into the right atrium as I did not place them. Also, I am not certain I could have traversed the occlusion from the femoral vein. I am not certain I could cross the SVC occlusion given the same scenario on a different day. I think you point is a good one and is always one of my Plan C's. What I learned here was why I was always taught to put the guidewire into the IVC and how even the more straight forward procedures can go awry in a few seconds. The first stent appeared to deploy appropriately. It looks to me that it is in the same position as the second one. I think the tight stenosis caused to "watermelon seed" forward. I had not seen this with a bare metal stent but had seen it many times with covered stents. Many times, I find that access work can be a chess game.
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Marc Webb says...
Posted Sunday, January 1, 2017
Dr. Gabbard - I agree with your point, commiserate with your problem, and applaud your management of the stent embolization. I should be so lucky, or so smart.
I personally don't do femoral retrogrades except in "Oh, shit" moments, leaving them to my excellent and experienced IR colleague, Dr. Paul Arpasi (not an ASDIN member).
Several stray thoughts: if we are to count on a wire down the IVC to save us, it should be a stiff wire, or well down the IVC, as devices (introducers, balloons, Kumpe catheters, maybe stents) can drag the wire where they want to go rather than where the wire is ostensibly headed.
Secondly, it is a reflection on how little the third-party payors value this work and how reimbursements are declining, that many of us are working like squirrels on a wheel, or robots rushing through our list. We are being forced to choose between economic survival and quality care in some instances. I know I have felt that dilemma.
Third, in the ecstasy of problem solving it is hard to stop - and then sometimes we find that we have gone too far. I'm sure you would have disappointed everyone had you aborted the procedure and rescheduled or sent the patient to the hospital. Again, I have found myself going a step or more beyond where I should have stopped. One of my nurses had three rules: "Stick to your first thought"; "Know when to stop"; and "Don't mess up lunch" - priorities.
And last, we actually have an identical patient with symptomatic SVC syndrome and reluctantly decided not to stent due to the very low nature of the occlusion and risk of stent displacement. We sent her to the U, thinking they might have some modality to actually remove the obstructing tissue short of a thoracotomy, but they did not, and discharged her on coumadin with swollen face and hands. They had nothing we didn't have.
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Marc Webb says...
Posted Sunday, January 1, 2017
I promise to shut up after this. Access can be like a chess game, or a combination of "Musical chairs" and "Hot potato". There is no shared risk - when the music stops while you are holding the potato, you are totally alone, no matter how many bad decisions were made before you agreed to help the patient. I used to be flattered when I was told "We only send you the hard cases since you are out of network". Now I realize I'm being dumped on, and accepting accumulated risk. If you think that anyone will understand that, and cut you some slack, you may find yourself sadly mistaken.
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Wesley A. Gabbard says...
Posted Sunday, January 1, 2017
Dr. Webb.
You are totally correct. I have been more times than I care to admit feeling like my butt is on the line, but the hospitals and Universities typically do worse work than the free-standing centers. So much of the time, I knew what I could do and realized the patient would worse if did not "try" something. A surgeon colleague actually told me that he would have pulled the wire and let the stent embolize. To me, that would be like giving the patient a bolus of 200 mEq of KCl.
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venkatesh rajkumar says...
Posted Monday, January 2, 2017
dear Dr. Wesley A. Gabbard,
A lot of learning in the case, thanks. A 14mm stent has already migrated. Can we try a 16mm stent instead for the repeat attempt?
pardon my ignorance please.
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Wesley A. Gabbard says...
Posted Monday, January 2, 2017
Hi Dr. Rajkumar,
That is a good question. I still thought that 14mm was proper sizing. But, that is a good point.
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Marc Webb says...
Posted Monday, January 2, 2017
Sounds like you need a new surgeon, or your surgeon needs treatment for burnout and depersonalization
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Mukesh K. Sharma says...
Posted Tuesday, January 3, 2017
Dr. Gabbard, what a great case ! Thank you for sharing with us and for some great teachers no points. I have a few questions if you don't mind:
1. You said that the 14mm balloon was unable to push the migrated stent and you had to use a larger 18mm balloon. I work at two vascular centers and none of them carry a balloon larger than 14mm. What would you do if you didn't have a balloon bigger than 14mm that day?
2. I see the rationale of using a bare metal stent in such scenarios. What if a stent graft migrates in similar situations and you are left with no option other than pushing it into IVC. Would you be worried about the stent graft jailing anything important inn the IVC? And is there a good lodging position in IVC for migrated stents such as in above case ?

Thank you again !
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Mukesh K. Sharma says...
Posted Tuesday, January 3, 2017
PS: sorry for the typo above: great teaching points !
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Wesley A. Gabbard says...
Posted Tuesday, January 3, 2017
Dr. Sharma, those are good questions. First, I would ask your centers to obtain 16mm and 18mm Atlas Gold balloons. They are not used often, but when needed, there is little options. Without the balloon, I probably would have tried to snare the stent from a femoral approach and pull it into the IVC. As I stated, the IVC takeoff appeared to have a bit of an anterior angle. I am not certain if this was his body habitus or his short thorax. Anyway, the stent kept cathching in the heart. The 14mm balloon kept slipping out of the stent. The 18mm balloon over-sized enough that it overlapped on both sides of the stent.
I think a stent-graft would be difficult to place here. His thorax was so short, that the left innominate would most certainly had been covered. As far as to where to place the embolized stent, I passed it into the IVC until it would not move more distally. Then, I seated it with the 18mm balloon after I shot an angiogram confirming I was in the IVC. I am not certain I would worry too much about jailing off veins in the IVC. Although it is possible, as long as the stent-graft were placed as distal as possible, I doubt any veins of consequence would be covered. Also, it is many times difficult to see any branches coming off the IVC on an antegrade image. Believe me, I just hope I do not have this happen again.
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Mukesh K. Sharma says...
Posted Tuesday, January 3, 2017
Thank you Dr. Gabbard ! Great points.
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Daniel V. Patel says...
Posted Tuesday, January 3, 2017
The use of a large balloon to move the migrated stent is reasonable in this unique scenario.

The biggest problem with 16 or 18 mm balloons for angioplasty is the risk of any possible vessel rupture. Stent-grafts do not come in diameters that big - and an SVC rupture could be fatal ( I have seen several cases). I usually don't go above 14mm in size for routine cases outpatient (and even then, I don't like getting much bigger than 12mm for most cases). Most of the time, you’ll have adequate treatment with a 12mm balloon.

Another issue with the Vaccess/ Atlas balloons at larger sizes is that they are very rigid - with no compliance and no conformity to the twists and turns of the central vessels. I feel this could lead to higher possibilities of central vessel rupture. The Direct Access First Choice balloon is a bit more “compliant” at 12 and 14mm.

Given the higher risks of trouble with larger PTA sizes, I’m generally not a huge fan of larger diameter 16-18 mm PTA as an outpatient. Even if you’re at an inpatient setting –these risks still play a role.

Usually the SVC can be left alone, but I can appreciate the extremely rare situations where you have to do something. But most of the time, our issues are at the innominate/ brachiocephalic veins and not the more central SVC.

As previously mentioned, I would have approached this from the groin, with a snare ( I use the Merit Ensare) and a 20F Femoral sheath, so I could pull the stent out. If the stent could not be removed, you could at least park it at the iliac vein. If the groin could not be accessed, the left-sided approach may have been considered from the existing catheter site.

But the overall outcome here is a reasonable bail-out – you did get yourself out of trouble and I do appreciate you sharing this case with lots to learn from. It’s a good reminder to everyone to securely place a wire down the IVC when doing central interventions.
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Lost in this discussion was the question was the point of getting into this scenario - did the facial edema completely resolve after the procedure?

Was it truly SVC syndrome, or just relative occlusion of the IJ/ Central veins from the cephalad right-sided catheter venotomy site?

Although you did have SVC narrowing on your CT imaging, I wonder if you would have improved symptoms by just correctly placing the catheter and performing a simple PTA. Even with recoil, it may have opened the vessel enough – there is no high flow access leading to the central occlusion, just the normal venous drainage from the head/ chest. True SVC syndrome without the presence of a functioning fistula/graft is extremely rare.

Another concern here is for long-term risks for in-stent bare metal stenosis in this patient. Should this occur, your only feasible approaches for intervention would be from the groin or the IJ catheter site.

Finally, the catheter will be in fairly close proximity to these stents – although rare, you do have to at least consider the risks for a central stent infection.

Just some points to consider, thanks again for sharing this case and helping us all to get better at what we do.

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Bharvi P. Oza-Gajera says...
Posted Tuesday, January 3, 2017
Great case and much to learn from the case as well as the comments. As a relatively new interventionalist (2 yrs out), I find this incredibly valuable. I do have a beginner question - I'm assuming that you attempt to use the same size or larger in this case balloon to engage a stent that has embolized - would this be at the nominal pressure? Do you then move the stent + balloon within the vessel at that pressure to the desired location? And then how exactly do you seat the stent -- increase pressure or does the decreased diameter of the vessel in and of itself provide enough apposition? Thank you and again, pardon my ignorance!
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Wesley A. Gabbard says...
Posted Tuesday, January 3, 2017
These are good questions. As far as to Dr. Patel's questions, the patient did not live too much longer after this procedure. He was failing everything, and, eventually, even failed PD. He had an iliac artery to iliac vein abdominal loop graft that failed when his iliac artery occluded due progression of his severe PAD.
Although there is risk for rupture of the great veins, even bare metal stents can tamponade vessel ruptures when needed. Also, I have over-sized the 13.5 mm Viabahn to 16 mm in certain situations. Additionally, the times that a 16mm or 18mm balloon is needed is rare, but they do occur.
In response to Dr. Oza-Gajera, I used as much pressure as the balloon could withstand to grab the stent. The goal here was to move the stent out of the heart. I actually over-sized the stent with the 18mm balloon in the IVC to make certain it was "parked" after moving it. I have pulled stents out using large sheaths and a snare, but this takes time as well as a patent femoral vein. I was lucky enough that I attempted to declot his iliac artery to iliac vein loop graft the following week and was able to check the position of the embolized stent. It had not moved. Unfortunately, at that time, this patient had had total access failure as was started on PD (which also failed).
Also, I am not certain that placing a catheter through 90% recoil would have worked or kept him from having symptoms. With his swollen head, he was symptomatic. Additionally, in the area where I was practicing, if the patient was admitted to the hospital with a catheter issue, the likelihood that this catheter might get removed was quite significant. I am not certain if the catheter were removed that I would be lucky enough to cross the SVC occlusion again. I looked at stenting his SVC as somewhat palliative as well as giving a functioning catheter. At the time, he was failing although he was unwilling to give up.
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Saravanan Balamuthusamy MD says...
Posted Tuesday, January 3, 2017
Removing bare metal stents are relatively easier. I can share the method i have used to retrieve migrated stents. If the wire is maintained , i would recommend using a 11 Fr 40-70 cm sheath and advance the sheath across the stent and then a goose snare through the sheath and deploy the snare above the stent and pullback to capture the distal end of the stent. I would suggest to snare and bend the stent over and then advance the sheath over the snare and then pull the stent back into the sheath.
I have used this technique to retrieve covered stents as well.
Using a larger balloon is a good idea, but its good to use a longer balloon than the stent length to avoid the vessel injury from the prongs while the stent is being pulled. Rupture of venous valves is not uncommon while stents are being pulled across a vein.
The Viabagns are the most easiest to retrieve as there is least likelihood of vessel damage and also they tend to bend a lot more easily than the stents with more memory.
My suggestion on stents that have migrated into the heart, kindly remove them in the hospital. Its not about one's skill, its more about the preparedness to manage complications which is not limited to valve rupture.

Regarding back-up for ruptures when 14mm balloons are used, if the SVC ruptures with angioplasty, no matter what stent one has, the patient would not leave the table alive. However, if the rupture occurs in the veins outside the chest wall, it is necessary to have a covered atrium cast stent ( used in IVC's or aortas) for salvage.These stents are prohibitively expensive and need larger sheaths and come in sizes more than 28mm diameter . Have used them to stent across a completely occluded IVC filter in a hospital lab.
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Wesley A. Gabbard says...
Posted Tuesday, January 3, 2017
I have snared a stent in a similar fashion.
Being able to remove such a stent after transfer to the hospital is difficult where I was practicing.
Although I place stent-grafts for a rupture (even with a larger vein), I have used a bare metal stent with tamponade to close a rupture (I did not have a large enough stent-graft at the time). I have also intentionally thrombosed an access that I could not control an extravasation even with a covered stent (the vein fell apart). I placed a catheter and confirmed the extravasation had thrombosed using ultrasound. As expected, the access was abandoned (it had not matured enough to be used in the first place).
Great teaching points!
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Marc Webb says...
Posted Wednesday, January 4, 2017
Philosophical view: we spend so much time and effort to preserve life, but these lives are already mostly spent. Even at 49, the mean survival of an ESRD patient is seven to ten years. With this history, and these co-morbidities, this patient can not be predicted to live that long. In the back of my mind I ask myself, "What am I protecting? How much should I subject the patient to? What is the "Win"?. A painless, peaceful death, perhaps.
A story - we had a patient who came with liver failure, and a history of cholangiocarcinoma resected elsewhere with positive margins. We did everything you could do to identify a residual malignancy prior to transplant, but found nothing. At the time of liver resection as a part of transplantation, a mass was found behind the liver, biopsy proven to be cholangiocarcinoma. I was not present, but according to one of the participants, the lead surgeon said, "Well, there is only one thing to do", and took the clamp off the suprahepatic IVC.
This is an extreme case, to be sure - but I think we go overboard to knit up a rotting sail - it's not always going to work.... it's not always going to solve anything .... and it's going to interfere with the logical and sensitive management of a patient's death.
This is a philosophical point, and not meant to be a criticism of the management of this case.
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Wesley A. Gabbard says...
Posted Wednesday, January 4, 2017
Nice thoughts, Dr. Webb. Not all of the subsequent procedures were done by me. This is not an excuse. The patient did want to give up without trying any and all options.
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